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Salience Clinical, LLC
For more than half a century, major depressive disorder (MDD) has largely been interpreted through a neurochemical lens. The prevailing framework focused on deficiencies or imbalances in serotonin, norepinephrine, and dopamine, leading to generations of therapies designed to modulate synaptic signaling.
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The Architectural Turn in Depression Why Network Topology Will Redefine CNS Strategy | #salience Clinical # LLC

The Architectural Turn in Depression Why Network Topology Will Redefine CNS Strategy

The Architectural Turn in Depression Why Network Topology Will Redefine CNS Strategy

For decades, psychiatry has framed major depressive disorder (MDD) as a disorder of chemistry, an imbalance of serotonin, norepinephrine, or dopamine.

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Advances in molecular diagnostics, computational neuroscience, fluid biomarkers, and digital phenotyping are enabling CNS disorders to be reclassified according to biological signatures, neural circuit dysfunction, and measurable disease trajectories. Precision neurology is no longer a future concept; it is becoming the operational foundation of successful CNS development strategy.

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