Physical Security plays a vital role in protecting enterprise assets, employees, and sensitive information from unauthorized access and real-world threats. Core best practices include layered access control systems, integrated CCTV surveillance, trained security personnel, and continuous risk assessment. In today’s evolving threat landscape, modern protection strategies are increasingly strengthened with AI-based monitoring and IoT-enabled sensors for faster detection and response. Physical Security frameworks that integrate these advanced technologies help organizations reduce operational risks, improve incident prevention, and ensure compliance with safety standards. This guide outlines practical strategies for building a resilient enterprise security structure suitable for businesses of all sizes. It also reflects insights aligned with International Security Journal research, highlighting global trends shaping the future of security infrastructure and enterprise protection systems.